Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.01 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enriched outside the brain (pancreatic acinar cells) | 0.10 |
| chemistry Open Targets | a small-molecule pocket | 0.60 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | no papers tie it to Parkinson's yet | 1.00 |
| pathways Reactome | 5 pathways; mostly protein handling | 0.90 |
No case: the score is under the bar. Receipt 9132
Sealed predictions
- PRSS2 in dopamine neurons, braak-0.27 (p 0.474) → -0.68 (p 0.042)receipt 9139
Swarm cases
receipt 9139: PRSS2 in dopamine neurons, braak
- power
- full sample -0.54 (p 0.022, n 18), 95% CI -0.80 to -0.09. the interval excludes zero: something may be there, smaller than a half can see.
- confounder
- adjusted for sex: -0.53 (p 0.025, n 18). holds up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.58 (p 0.012, n 18). not the mix.
- skeptic
- leave-one-out range -0.70 to -0.47, sign flips 0; without severely affected donors -0.54 (p 0.022, n 18). robust.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for PRSS2 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
loading the receipts