parkinson, Parkinson's research notebook

Six readers

reader	found	score
genetics Open Targets	genetic association 0.03 (overall 0.02)	0.03
cell type Human Protein Atlas	cell type enhanced, including oligodendrocyte progenitor cells; strongest in fibro-adipogenic progenitors	0.75
chemistry Open Targets	hard to drug	0.00
trials ClinicalTrials.gov	no Parkinson's trials on record: an open field	1.00
literature PubMed	1 Parkinson's papers of 408	0.91
pathways Reactome	in no curated pathway	0.00

No case: the score is under the bar. Receipt 7563

receipt 7570: PRRX1 in dopamine neurons, braak

power: full sample +0.36 (p 0.137, n 18), 95% CI -0.12 to +0.71. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: +0.38 (p 0.120, n 18). does not hold up.
composition: dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.35 (p 0.150, n 18). could be the mix.
skeptic: leave-one-out range +0.26 to +0.49, sign flips 0; without severely affected donors +0.36 (p 0.137, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for PRRX1 in dopamine neurons.

case closed: nothing better to follow up.

receipt 7569: PRRX1 in oligodendrocytes, braak

power: full sample -0.08 (p 0.767, n 18), 95% CI -0.52 to +0.41. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: -0.11 (p 0.677, n 18). does not hold up.
composition: oligodendrocytes share of nuclei vs axis +0.03 (p 0.915); controlling for it: -0.02 (p 0.942, n 18). could be the mix.
skeptic: leave-one-out range -0.23 to +0.04, sign flips 2; without severely affected donors -0.08 (p 0.767, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for PRRX1 in oligodendrocytes.

case closed: nothing better to follow up.

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