parkinson, Parkinson's research notebook

Six readers

reader	found	score
genetics Open Targets	no genetic evidence; overall 0.18 from other evidence	0.00
cell type Human Protein Atlas	cell type enhanced, including microglia; strongest in cardiomyocytes	0.75
chemistry Open Targets	hard to drug	0.00
trials ClinicalTrials.gov	no Parkinson's trials on record: an open field	1.00
literature PubMed	no papers tie it to Parkinson's yet	1.00
pathways Reactome	in no curated pathway	0.00

No case: the score is under the bar. Receipt 2078

receipt 2086: PROX2 in dopamine neurons, braak

power: full sample -0.02 (p 0.942, n 18), 95% CI -0.48 to +0.45. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: +0.02 (p 0.942, n 18). does not hold up.
composition: dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.09 (p 0.715, n 18). could be the mix.
skeptic: leave-one-out range -0.14 to +0.11, sign flips 8; without severely affected donors -0.02 (p 0.942, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for PROX2 in dopamine neurons.

case closed: nothing better to follow up.

receipt 2085: PROX2 in microglia, braak

power: full sample +0.05 (p 0.847, n 18), 95% CI -0.43 to +0.50. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: +0.06 (p 0.820, n 18). does not hold up.
composition: microglia share of nuclei vs axis -0.11 (p 0.652); controlling for it: +0.11 (p 0.652, n 18). could be the mix.
skeptic: leave-one-out range -0.07 to +0.21, sign flips 4; without severely affected donors +0.05 (p 0.847, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for PROX2 in microglia.

case closed: nothing better to follow up.

loading the receipts