Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.07 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enriched outside the brain (lactotrophs) | 0.10 |
| chemistry Open Targets | reachable by antibody | 0.45 |
| trials ClinicalTrials.gov | 10 Parkinson's trials, 0 stopped | 1.00 |
| literature PubMed | 76 Parkinson's papers of 18,865 | 0.43 |
| pathways Reactome | 4 pathways; mostly other | 0.30 |
No case: the score is under the bar. Receipt 3821
Sealed predictions
- PRL in dopamine neurons, braak-0.14 (p 0.714) → +0.46 (p 0.214)receipt 3829
Swarm cases
receipt 3829: PRL in dopamine neurons, braak
- power
- full sample -0.01 (p 0.962, n 18), 95% CI -0.48 to +0.46. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.07 (p 0.774, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.06 (p 0.814, n 18). could be the mix.
- skeptic
- leave-one-out range -0.14 to +0.11, sign flips 6; without severely affected donors -0.01 (p 0.962, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for PRL in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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