Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.37 from other evidence | 0.00 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | a small-molecule pocket | 0.60 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | no papers tie it to Parkinson's yet | 1.00 |
| pathways Reactome | 45 pathways; mostly protein handling | 0.90 |
No case: the score is under the bar. Receipt 0818
Sealed predictions
- PPP2R1A in dopamine neurons, braak+0.35 (p 0.362) → +0.40 (p 0.285)receipt 0826
Swarm cases
receipt 0826: PPP2R1A in dopamine neurons, braak
- power
- full sample +0.24 (p 0.332, n 18), 95% CI -0.25 to +0.64. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.23 (p 0.351, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.19 (p 0.450, n 18). could be the mix.
- skeptic
- leave-one-out range +0.14 to +0.32, sign flips 0; without severely affected donors +0.24 (p 0.332, n 18). fragile.
- cell type
- strongest in astrocytes: -0.63 (p 0.0055, n 18) vs +0.24 in dopamine neurons. proposing astrocytes.
- axis
- no measure beats "tracks Braak Lewy-body stage" for PPP2R1A in dopamine neurons.
follow-up registered; not confirmed in substantia nigra, an independent cohort.
follow-up PPP2R1A · astrocytes · braak: substantia nigra, an independent cohort (Parkinson's or LBD vs controls) +0.45 p 0.110 (needs p < 0.0015)
Receipts
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