Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.26 from other evidence | 0.00 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | compounds already reach it: lb-100 | 0.90 |
| trials ClinicalTrials.gov | 1 Parkinson's trial, 0 stopped | 1.00 |
| literature PubMed | 4 Parkinson's papers of 183 | 0.79 |
| pathways Reactome | 38 pathways; mostly protein handling | 0.90 |
No case: the score is under the bar. Receipt 1571
Sealed predictions
- PPP2CA in dopamine neurons, braak+0.79 (p 0.012) → +0.35 (p 0.360)receipt 1578
Swarm cases
receipt 1578: PPP2CA in dopamine neurons, braak
- power
- full sample +0.64 (p 0.0042, n 18), 95% CI +0.25 to +0.85. the interval excludes zero: something may be there, smaller than a half can see.
- confounder
- adjusted for sex: +0.64 (p 0.0042, n 18). holds up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.60 (p 0.0080, n 18). not the mix.
- skeptic
- leave-one-out range +0.60 to +0.80, sign flips 0; without severely affected donors +0.64 (p 0.0042, n 18). robust.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for PPP2CA in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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