parkinson, Parkinson's research notebook

Six readers

reader	found	score
genetics Open Targets	no genetic evidence; overall 0.03 from other evidence	0.00
cell type Human Protein Atlas	cell type enhanced in oligodendrocytes (444 nCPM)	1.00
chemistry Open Targets	hard to drug	0.00
trials ClinicalTrials.gov	no Parkinson's trials on record: an open field	1.00
literature PubMed	22 Parkinson's papers of 58	0.59
pathways Reactome	in no curated pathway	0.00

No case: the score is under the bar. Receipt 6773

receipt 6782: PPM1H in dopamine neurons, braak

power: full sample -0.13 (p 0.621, n 18), 95% CI -0.56 to +0.36. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: -0.13 (p 0.609, n 18). does not hold up.
composition: dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.13 (p 0.609, n 18). could be the mix.
skeptic: leave-one-out range -0.26 to -0.02, sign flips 0; without severely affected donors -0.13 (p 0.621, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for PPM1H in dopamine neurons.

case closed: nothing better to follow up.

receipt 6781: PPM1H in oligodendrocytes, braak

power: full sample -0.48 (p 0.043, n 18), 95% CI -0.77 to -0.02. the interval excludes zero: something may be there, smaller than a half can see.
confounder: adjusted for sex: -0.44 (p 0.064, n 18). does not hold up.
composition: oligodendrocytes share of nuclei vs axis +0.03 (p 0.915); controlling for it: -0.51 (p 0.030, n 18). not the mix.
skeptic: leave-one-out range -0.66 to -0.42, sign flips 0; without severely affected donors -0.48 (p 0.043, n 18). robust.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for PPM1H in oligodendrocytes.

case closed: nothing better to follow up.

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