Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Gene record

PPBP

pro-platelet basic protein

translation score 0.40, read 2026-10-21; 1 sealed predictions, 0 held; 2 receipts.

Six readers

readerfoundscore
genetics
Open Targets
no genetic evidence; overall 0.05 from other evidence0.00
cell type
Human Protein Atlas
group enriched outside the brain (platelets)0.10
chemistry
Open Targets
a small-molecule pocket0.60
trials
ClinicalTrials.gov
no Parkinson's trials on record: an open field1.00
literature
PubMed
2 Parkinson's papers of 2410.85
pathways
Reactome
4 pathways; mostly other0.30

No case: the score is under the bar. Receipt 5015

Sealed predictions

  1. PPBP in dopamine neurons, braakn/a → n/areceipt 5022

Swarm cases

receipt 5022: PPBP in dopamine neurons, braak

cell type
PPBP is not measured in dopamine neurons; looking elsewhere.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for PPBP in dopamine neurons.

case closed: nothing better to follow up.

Receipts

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