Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.06 from other evidence | 0.00 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | compounds already reach it: kd3010, cer-002, ave0847 +11 | 1.00 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 1 Parkinson's papers of 473 | 0.91 |
| pathways Reactome | 3 pathways; mostly growth signalling | 0.60 |
No case: the score is under the bar. Receipt 4604
Sealed predictions
- PPARD in dopamine neurons, braak+0.29 (p 0.456) → -0.34 (p 0.373)receipt 4611
Swarm cases
receipt 4611: PPARD in dopamine neurons, braak
- power
- full sample -0.11 (p 0.671, n 18), 95% CI -0.55 to +0.38. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.10 (p 0.683, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.41 (p 0.095, n 18). could be the mix.
- skeptic
- leave-one-out range -0.21 to +0.02, sign flips 4; without severely affected donors -0.11 (p 0.671, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for PPARD in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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