Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.01 from other evidence | 0.00 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | a small-molecule pocket | 0.60 |
| trials ClinicalTrials.gov | 12 Parkinson's trials, 1 stopped | 0.93 |
| literature PubMed | 19 Parkinson's papers of 8,248 | 0.61 |
| pathways Reactome | 1 pathway; mostly other | 0.30 |
No case: the score is under the bar. Receipt 9436
Sealed predictions
- POR in dopamine neurons, braak+0.01 (p 0.982) → -0.37 (p 0.334)receipt 9443
Swarm cases
receipt 9443: POR in dopamine neurons, braak
- power
- full sample -0.27 (p 0.277, n 18), 95% CI -0.65 to +0.22. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.31 (p 0.218, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.24 (p 0.337, n 18). could be the mix.
- skeptic
- leave-one-out range -0.39 to -0.17, sign flips 0; without severely affected donors -0.27 (p 0.277, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for POR in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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