Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.09 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enriched outside the brain (hepatocytes) | 0.10 |
| chemistry Open Targets | a small-molecule pocket | 0.60 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 60 Parkinson's papers of 3,738 | 0.46 |
| pathways Reactome | 2 pathways; mostly other | 0.30 |
No case: the score is under the bar. Receipt 2815
Sealed predictions
- PON1 in dopamine neurons, braak+0.48 (p 0.187) → +0.62 (p 0.074)receipt 2823
Swarm cases
receipt 2823: PON1 in dopamine neurons, braak
- power
- full sample +0.44 (p 0.067, n 18), 95% CI -0.03 to +0.75. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.43 (p 0.079, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.41 (p 0.087, n 18). could be the mix.
- skeptic
- leave-one-out range +0.38 to +0.58, sign flips 0; without severely affected donors +0.44 (p 0.067, n 18). robust.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for PON1 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
loading the receipts