Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.01 from other evidence | 0.00 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | a small-molecule pocket | 0.60 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 13 Parkinson's papers of 1,070 | 0.65 |
| pathways Reactome | 1 pathway; mostly dopamine synapse | 1.00 |
No case: the score is under the bar. Receipt 9295
Sealed predictions
- PNMT in dopamine neurons, braak-0.05 (p 0.893) → -0.42 (p 0.258)receipt 9302
Swarm cases
receipt 9302: PNMT in dopamine neurons, braak
- power
- full sample -0.21 (p 0.408, n 18), 95% CI -0.61 to +0.29. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.18 (p 0.471, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.18 (p 0.471, n 18). could be the mix.
- skeptic
- leave-one-out range -0.31 to -0.10, sign flips 0; without severely affected donors -0.21 (p 0.408, n 18). fragile.
- cell type
- strongest in microglia: -0.67 (p 0.0026, n 18) vs -0.21 in dopamine neurons. proposing microglia.
- axis
- no measure beats "tracks Braak Lewy-body stage" for PNMT in dopamine neurons.
follow-up registered; not confirmed in substantia nigra, an independent cohort.
follow-up PNMT · microglia · braak: substantia nigra, an independent cohort (Parkinson's or LBD vs controls) -0.28 p 0.328 (needs p < 2.3e-4)
Receipts
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