Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | genetic association 0.20 (overall 0.13) | 0.20 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | reachable by antibody | 0.45 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 4 Parkinson's papers of 108 | 0.79 |
| pathways Reactome | 6 pathways; mostly growth signalling | 0.60 |
No case: the score is under the bar. Receipt 2292
Sealed predictions
- PLXNA1 in dopamine neurons, braak-0.15 (p 0.699) → -0.53 (p 0.146)receipt 2298
Swarm cases
receipt 2298: PLXNA1 in dopamine neurons, braak
- power
- full sample -0.43 (p 0.077, n 18), 95% CI -0.75 to +0.05. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.43 (p 0.077, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.56 (p 0.017, n 18). not the mix.
- skeptic
- leave-one-out range -0.54 to -0.35, sign flips 0; without severely affected donors -0.43 (p 0.077, n 18). robust.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for PLXNA1 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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