Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.28 from other evidence | 0.00 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | a small-molecule pocket | 0.60 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 8 Parkinson's papers of 245 | 0.71 |
| pathways Reactome | 3 pathways; mostly protein handling | 0.90 |
No case: the score is under the bar. Receipt 1437
Sealed predictions
- PLK3 in dopamine neurons, braak-0.72 (p 0.029) → -0.51 (p 0.163)receipt 1441
Swarm cases
receipt 1441: PLK3 in dopamine neurons, braak
- power
- full sample -0.50 (p 0.036, n 18), 95% CI -0.78 to -0.04. the interval excludes zero: something may be there, smaller than a half can see.
- confounder
- adjusted for sex: -0.47 (p 0.047, n 18). holds up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.52 (p 0.026, n 18). not the mix.
- skeptic
- leave-one-out range -0.60 to -0.43, sign flips 0; without severely affected donors -0.50 (p 0.036, n 18). robust.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for PLK3 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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