Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.07 from other evidence | 0.00 |
| cell type Human Protein Atlas | group enriched outside the brain (hepatocytes) | 0.10 |
| chemistry Open Targets | compounds already reach it: aminocaproic acid, amediplase, desmoteplase +6 | 1.00 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 21 Parkinson's papers of 2,160 | 0.59 |
| pathways Reactome | 6 pathways; mostly protein handling | 0.90 |
No case: the score is under the bar. Receipt 3789
Sealed predictions
- PLG in dopamine neurons, braak+0.45 (p 0.227) → +0.13 (p 0.741)receipt 3796
Swarm cases
receipt 3796: PLG in dopamine neurons, braak
- power
- full sample +0.35 (p 0.153, n 18), 95% CI -0.14 to +0.70. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.37 (p 0.135, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.46 (p 0.052, n 18). could be the mix.
- skeptic
- leave-one-out range +0.27 to +0.45, sign flips 0; without severely affected donors +0.35 (p 0.153, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for PLG in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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