Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Gene record

PLEKHM1

pleckstrin homology and RUN domain containing M1

translation score 0.48, read 2026-10-18; 2 sealed predictions, 0 held; 3 receipts.

Six readers

readerfoundscore
genetics
Open Targets		genetic association 0.20 (overall 0.13)0.20
cell type
Human Protein Atlas		cell type enhanced, including oligodendrocytes; strongest in papillary tip epithelial cells0.75
chemistry
Open Targets		a small-molecule pocket0.60
trials
ClinicalTrials.gov		no Parkinson's trials on record: an open field1.00
literature
PubMed		11 Parkinson's papers of 920.67
pathways
Reactome		in no curated pathway0.00

No case: the score is under the bar. Receipt 2238

Sealed predictions

  1. PLEKHM1 in oligodendrocytes, braak-0.54 (p 0.133) → -0.32 (p 0.407)receipt 2244
  2. PLEKHM1 in dopamine neurons, braak-0.68 (p 0.042) → -0.11 (p 0.775)receipt 2245

Swarm cases

receipt 2245: PLEKHM1 in dopamine neurons, braak

power
full sample -0.29 (p 0.239, n 18), 95% CI -0.67 to +0.20. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: -0.27 (p 0.273, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.38 (p 0.120, n 18). could be the mix.
skeptic
leave-one-out range -0.45 to -0.23, sign flips 0; without severely affected donors -0.29 (p 0.239, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for PLEKHM1 in dopamine neurons.

case closed: nothing better to follow up.

receipt 2244: PLEKHM1 in oligodendrocytes, braak

power
full sample -0.51 (p 0.031, n 18), 95% CI -0.79 to -0.05. the interval excludes zero: something may be there, smaller than a half can see.
confounder
adjusted for sex: -0.55 (p 0.018, n 18). holds up.
composition
oligodendrocytes share of nuclei vs axis +0.03 (p 0.915); controlling for it: -0.57 (p 0.014, n 18). not the mix.
skeptic
leave-one-out range -0.61 to -0.44, sign flips 0; without severely affected donors -0.51 (p 0.031, n 18). robust.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for PLEKHM1 in oligodendrocytes.

case closed: nothing better to follow up.

Receipts

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