parkinson, Parkinson's research notebook

Six readers

reader	found	score
genetics Open Targets	no genetic evidence; overall 0.01 from other evidence	0.00
cell type Human Protein Atlas	cell type enhanced in oligodendrocytes (577 nCPM)	1.00
chemistry Open Targets	a small-molecule pocket	0.60
trials ClinicalTrials.gov	no Parkinson's trials on record: an open field	1.00
literature PubMed	6 Parkinson's papers of 910	0.74
pathways Reactome	8 pathways; mostly other	0.30

No case: the score is under the bar. Receipt 9458

receipt 9466: PLD1 in dopamine neurons, braak

power: full sample -0.02 (p 0.942, n 18), 95% CI -0.48 to +0.45. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: -0.04 (p 0.874, n 18). does not hold up.
composition: dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.22 (p 0.384, n 18). could be the mix.
skeptic: leave-one-out range -0.17 to +0.11, sign flips 6; without severely affected donors -0.02 (p 0.942, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for PLD1 in dopamine neurons.

case closed: nothing better to follow up.

receipt 9465: PLD1 in oligodendrocytes, braak

power: full sample +0.09 (p 0.735, n 18), 95% CI -0.40 to +0.53. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: +0.12 (p 0.640, n 18). does not hold up.
composition: oligodendrocytes share of nuclei vs axis +0.03 (p 0.915); controlling for it: +0.07 (p 0.794, n 18). could be the mix.
skeptic: leave-one-out range +0.01 to +0.24, sign flips 0; without severely affected donors +0.09 (p 0.735, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for PLD1 in oligodendrocytes.

case closed: nothing better to follow up.

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