Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.00 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enhanced, including brain inhibitory neurons; strongest in salivary acinar cells | 0.75 |
| chemistry Open Targets | hard to drug | 0.27 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 2 Parkinson's papers of 205 | 0.85 |
| pathways Reactome | 8 pathways; mostly dopamine synapse | 1.00 |
No case: the score is under the bar. Receipt 13379
Sealed predictions
- PLCB1 in dopamine neurons, braak+0.34 (p 0.375) → +0.60 (p 0.089)receipt 13386
Swarm cases
receipt 13386: PLCB1 in dopamine neurons, braak
- power
- full sample +0.48 (p 0.045, n 18), 95% CI +0.01 to +0.77. the interval excludes zero: something may be there, smaller than a half can see.
- confounder
- adjusted for sex: +0.47 (p 0.047, n 18). holds up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.51 (p 0.031, n 18). not the mix.
- skeptic
- leave-one-out range +0.41 to +0.63, sign flips 0; without severely affected donors +0.48 (p 0.045, n 18). robust.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for PLCB1 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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