Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.00 from other evidence | 0.00 |
| cell type Human Protein Atlas | group enriched outside the brain (lacrimal acinar cells) | 0.10 |
| chemistry Open Targets | reachable by antibody | 0.45 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 32 Parkinson's papers of 10,445 | 0.54 |
| pathways Reactome | 1 pathway; mostly other | 0.30 |
No case: the score is under the bar. Receipt 16742
Sealed predictions
- PIP in dopamine neurons, braak+0.38 (p 0.318) → -0.12 (p 0.767)receipt 16749
Swarm cases
receipt 16749: PIP in dopamine neurons, braak
- power
- full sample +0.12 (p 0.633, n 18), 95% CI -0.37 to +0.56. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.15 (p 0.555, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.15 (p 0.544, n 18). could be the mix.
- skeptic
- leave-one-out range -0.01 to +0.19, sign flips 1; without severely affected donors +0.12 (p 0.633, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for PIP in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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