Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Gene record

PHYHIPL

phytanoyl-CoA 2-hydroxylase interacting protein like

translation score 0.41, read 2026-10-21; 2 sealed predictions, 0 held; 3 receipts.

Six readers

readerfoundscore
genetics
Open Targets		no genetic evidence; overall 0.04 from other evidence0.00
cell type
Human Protein Atlas		cell type enhanced, including oligodendrocytes; strongest in bergmann glia0.75
chemistry
Open Targets		hard to drug0.00
trials
ClinicalTrials.gov		no Parkinson's trials on record: an open field1.00
literature
PubMed		no papers tie it to Parkinson's yet1.00
pathways
Reactome		in no curated pathway0.00

No case: the score is under the bar. Receipt 5640

Sealed predictions

  1. PHYHIPL in dopamine neurons, braak+0.21 (p 0.586) → +0.11 (p 0.787)receipt 5649
  2. PHYHIPL in oligodendrocytes, braak+0.00 (p 1.000) → +0.41 (p 0.272)receipt 5648

Swarm cases

receipt 5649: PHYHIPL in dopamine neurons, braak

power
full sample +0.00 (p 0.990, n 18), 95% CI -0.46 to +0.47. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: -0.04 (p 0.881, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.04 (p 0.888, n 18). could be the mix.
skeptic
leave-one-out range -0.12 to +0.13, sign flips 10; without severely affected donors +0.00 (p 0.990, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for PHYHIPL in dopamine neurons.

case closed: nothing better to follow up.

receipt 5648: PHYHIPL in oligodendrocytes, braak

power
full sample +0.24 (p 0.332, n 18), 95% CI -0.25 to +0.64. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: +0.24 (p 0.332, n 18). does not hold up.
composition
oligodendrocytes share of nuclei vs axis +0.03 (p 0.915); controlling for it: +0.38 (p 0.120, n 18). could be the mix.
skeptic
leave-one-out range +0.14 to +0.39, sign flips 0; without severely affected donors +0.24 (p 0.332, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for PHYHIPL in oligodendrocytes.

case closed: nothing better to follow up.

Receipts

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