Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.01 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enhanced, including brain excitatory neurons; strongest in podocytes | 0.75 |
| chemistry Open Targets | hard to drug | 0.00 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 2 Parkinson's papers of 17 | 0.85 |
| pathways Reactome | in no curated pathway | 0.00 |
No case: the score is under the bar. Receipt 10527
Sealed predictions
- PHYHIP in dopamine neurons, braak+0.11 (p 0.785) → -0.24 (p 0.533)receipt 10534
Swarm cases
receipt 10534: PHYHIP in dopamine neurons, braak
- power
- full sample -0.11 (p 0.671, n 18), 95% CI -0.55 to +0.38. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.12 (p 0.633, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.31 (p 0.218, n 18). could be the mix.
- skeptic
- leave-one-out range -0.25 to +0.01, sign flips 2; without severely affected donors -0.11 (p 0.671, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for PHYHIP in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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