Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | genetic association 0.11 (overall 0.07) | 0.11 |
| cell type Human Protein Atlas | cell type enhanced, including brain excitatory neurons; strongest in enterocytes | 0.75 |
| chemistry Open Targets | hard to drug | 0.00 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | no papers tie it to Parkinson's yet | 1.00 |
| pathways Reactome | in no curated pathway | 0.00 |
No case: the score is under the bar. Receipt 3951
Sealed predictions
- PDLIM2 in dopamine neurons, braak-0.59 (p 0.092) → -0.27 (p 0.474)receipt 3958
Swarm cases
receipt 3958: PDLIM2 in dopamine neurons, braak
- power
- full sample -0.45 (p 0.063, n 18), 95% CI -0.76 to +0.03. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.39 (p 0.111, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.52 (p 0.026, n 18). not the mix.
- skeptic
- leave-one-out range -0.52 to -0.37, sign flips 0; without severely affected donors -0.45 (p 0.063, n 18). robust.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for PDLIM2 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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