Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.02 from other evidence | 0.00 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | compounds already reach it: sodium dichloroacetate | 1.00 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 10 Parkinson's papers of 3,127 | 0.69 |
| pathways Reactome | 3 pathways; mostly mitochondrial quality control | 1.00 |
No case: the score is under the bar. Receipt 7884
Sealed predictions
- PDK1 in dopamine neurons, braak+0.77 (p 0.014) → +0.13 (p 0.738)receipt 7891
Swarm cases
receipt 7891: PDK1 in dopamine neurons, braak
- power
- full sample +0.62 (p 0.0062, n 18), 95% CI +0.21 to +0.84. the interval excludes zero: something may be there, smaller than a half can see.
- confounder
- adjusted for sex: +0.66 (p 0.0030, n 18). holds up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.65 (p 0.0034, n 18). not the mix.
- skeptic
- leave-one-out range +0.56 to +0.72, sign flips 0; without severely affected donors +0.62 (p 0.0062, n 18). robust.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for PDK1 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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