Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.08 from other evidence | 0.00 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | compounds already reach it: pentoxifylline, dipyridamole | 1.00 |
| trials ClinicalTrials.gov | 1 Parkinson's trial, 0 stopped | 1.00 |
| literature PubMed | 1 Parkinson's papers of 332 | 0.91 |
| pathways Reactome | 3 pathways; mostly other | 0.30 |
No case: the score is under the bar. Receipt 3599
Sealed predictions
- PDE6B in dopamine neurons, braak-0.12 (p 0.767) → -0.36 (p 0.344)receipt 3607
Swarm cases
receipt 3607: PDE6B in dopamine neurons, braak
- power
- full sample -0.31 (p 0.207, n 18), 95% CI -0.68 to +0.18. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.26 (p 0.306, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.24 (p 0.337, n 18). could be the mix.
- skeptic
- leave-one-out range -0.40 to -0.21, sign flips 0; without severely affected donors -0.31 (p 0.207, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for PDE6B in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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