Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.08 from other evidence | 0.00 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | compounds already reach it: oglemilast, mk-0873, apremilast +25 | 1.00 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 2 Parkinson's papers of 332 | 0.85 |
| pathways Reactome | 2 pathways; mostly other | 0.30 |
No case: the score is under the bar. Receipt 3182
Sealed predictions
- PDE4A in dopamine neurons, braak-0.49 (p 0.181) → -0.51 (p 0.160)receipt 3189
Swarm cases
receipt 3189: PDE4A in dopamine neurons, braak
- power
- full sample -0.39 (p 0.105, n 18), 95% CI -0.73 to +0.09. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.39 (p 0.105, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.48 (p 0.046, n 18). not the mix.
- skeptic
- leave-one-out range -0.53 to -0.32, sign flips 0; without severely affected donors -0.39 (p 0.105, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for PDE4A in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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