parkinson, Parkinson's research notebook

Six readers

reader	found	score
genetics Open Targets	no genetic evidence; overall 0.02 from other evidence	0.00
cell type Human Protein Atlas	cell type enhanced, including microglia; strongest in extravillous trophoblasts	0.75
chemistry Open Targets	compounds already reach it: rhigm12b7	0.72
trials ClinicalTrials.gov	63 Parkinson's trials, 3 stopped	0.95
literature PubMed	no papers tie it to Parkinson's yet	1.00
pathways Reactome	2 pathways; mostly other	0.30

No case: the score is under the bar. Receipt 7756

PDCD1LG2 in microglia, braak-0.39 (p 0.300) → +0.25 (p 0.517)receipt 7763
PDCD1LG2 in dopamine neurons, braak+0.25 (p 0.514) → +0.04 (p 0.925)receipt 7764

receipt 7764: PDCD1LG2 in dopamine neurons, braak

power: full sample +0.16 (p 0.521, n 18), 95% CI -0.33 to +0.58. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: +0.22 (p 0.384, n 18). does not hold up.
composition: dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.09 (p 0.709, n 18). could be the mix.
skeptic: leave-one-out range +0.06 to +0.29, sign flips 0; without severely affected donors +0.16 (p 0.521, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for PDCD1LG2 in dopamine neurons.

case closed: nothing better to follow up.

receipt 7763: PDCD1LG2 in microglia, braak

power: full sample -0.08 (p 0.761, n 18), 95% CI -0.53 to +0.40. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: -0.10 (p 0.683, n 18). does not hold up.
composition: microglia share of nuclei vs axis -0.11 (p 0.652); controlling for it: +0.04 (p 0.861, n 18). could be the mix.
skeptic: leave-one-out range -0.19 to +0.07, sign flips 5; without severely affected donors -0.08 (p 0.761, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for PDCD1LG2 in microglia.

case closed: nothing better to follow up.

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