Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.01 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enhanced, including oligodendrocytes; strongest in late spermatids | 0.75 |
| chemistry Open Targets | hard to drug | 0.00 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | no papers tie it to Parkinson's yet | 1.00 |
| pathways Reactome | 1 pathway; mostly other | 0.30 |
No case: the score is under the bar. Receipt 10274
Sealed predictions
- PCYT1B in dopamine neurons, braak+0.07 (p 0.849) → +0.18 (p 0.635)receipt 10281
- PCYT1B in oligodendrocytes, braak-0.21 (p 0.581) → -0.05 (p 0.894)receipt 10280
Swarm cases
receipt 10281: PCYT1B in dopamine neurons, braak
- power
- full sample +0.15 (p 0.555, n 18), 95% CI -0.34 to +0.58. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.09 (p 0.728, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.09 (p 0.709, n 18). could be the mix.
- skeptic
- leave-one-out range +0.02 to +0.27, sign flips 0; without severely affected donors +0.15 (p 0.555, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for PCYT1B in dopamine neurons.
case closed: nothing better to follow up.
receipt 10280: PCYT1B in oligodendrocytes, braak
- power
- full sample -0.16 (p 0.538, n 18), 95% CI -0.58 to +0.34. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.03 (p 0.894, n 18). does not hold up.
- composition
- oligodendrocytes share of nuclei vs axis +0.03 (p 0.915); controlling for it: -0.01 (p 0.976, n 18). could be the mix.
- skeptic
- leave-one-out range -0.33 to -0.08, sign flips 0; without severely affected donors -0.16 (p 0.538, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for PCYT1B in oligodendrocytes.
case closed: nothing better to follow up.
Receipts
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