Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | genetic association 0.13 (overall 0.43) | 0.13 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | a small-molecule pocket | 0.60 |
| trials ClinicalTrials.gov | 1 Parkinson's trial, 0 stopped | 1.00 |
| literature PubMed | 2 Parkinson's papers of 62 | 0.85 |
| pathways Reactome | 1 pathway; mostly other | 0.30 |
No case: the score is under the bar. Receipt 0459
Sealed predictions
- PANK1 in dopamine neurons, braak+0.00 (p 1.000) → +0.78 (p 0.013)receipt 0465
Swarm cases
receipt 0465: PANK1 in dopamine neurons, braak
- power
- full sample +0.34 (p 0.173, n 18), 95% CI -0.16 to +0.69. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.29 (p 0.235, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.28 (p 0.258, n 18). could be the mix.
- skeptic
- leave-one-out range +0.25 to +0.48, sign flips 0; without severely affected donors +0.34 (p 0.173, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for PANK1 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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