Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.01 from other evidence | 0.00 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | compounds already reach it: sapropterin dihydrochloride, sapropterin | 1.00 |
| trials ClinicalTrials.gov | 42 Parkinson's trials, 3 stopped | 0.94 |
| literature PubMed | 18 Parkinson's papers of 33,373 | 0.61 |
| pathways Reactome | 2 pathways; mostly energy | 0.60 |
No case: the score is under the bar. Receipt 9207
Sealed predictions
- PAH in dopamine neurons, braak-0.27 (p 0.478) → +0.74 (p 0.023)receipt 9215
Swarm cases
receipt 9215: PAH in dopamine neurons, braak
- power
- full sample +0.22 (p 0.374, n 18), 95% CI -0.27 to +0.62. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.25 (p 0.323, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.06 (p 0.820, n 18). could be the mix.
- skeptic
- leave-one-out range +0.13 to +0.38, sign flips 0; without severely affected donors +0.22 (p 0.374, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for PAH in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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