Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.07 from other evidence | 0.00 |
| cell type Human Protein Atlas | group enriched outside the brain (neutrophil progenitors) | 0.10 |
| chemistry Open Targets | a small-molecule pocket | 0.60 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 1 Parkinson's papers of 492 | 0.91 |
| pathways Reactome | 1 pathway; mostly other | 0.30 |
No case: the score is under the bar. Receipt 3874
Sealed predictions
- PADI4 in dopamine neurons, braak+0.06 (p 0.877) → -0.59 (p 0.096)receipt 3881
Swarm cases
receipt 3881: PADI4 in dopamine neurons, braak
- power
- full sample -0.26 (p 0.302, n 18), 95% CI -0.65 to +0.24. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.26 (p 0.302, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.39 (p 0.114, n 18). could be the mix.
- skeptic
- leave-one-out range -0.41 to -0.17, sign flips 0; without severely affected donors -0.26 (p 0.302, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for PADI4 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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