Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Gene record

PACC1

proton activated chloride channel 1

translation score 0.50, read 2026-10-25; 2 sealed predictions, 0 held; 3 receipts.

Six readers

readerfoundscore
genetics
Open Targets
no genetic evidence; overall 0.01 from other evidence0.00
cell type
Human Protein Atlas
cell type enhanced in oligodendrocytes (99 nCPM)1.00
chemistry
Open Targets
a small-molecule pocket0.60
trials
ClinicalTrials.gov
no Parkinson's trials on record: an open field1.00
literature
PubMed
1 Parkinson's papers of 390.91
pathways
Reactome
in no curated pathway0.00

No case: the score is under the bar. Receipt 9867

Sealed predictions

  1. PACC1 in oligodendrocytes, braakn/a → n/areceipt 9874
  2. PACC1 in dopamine neurons, braakn/a → n/areceipt 9875

Swarm cases

receipt 9875: PACC1 in dopamine neurons, braak

cell type
PACC1 is not measured in dopamine neurons; looking elsewhere.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for PACC1 in dopamine neurons.

case closed: nothing better to follow up.

receipt 9874: PACC1 in oligodendrocytes, braak

cell type
PACC1 is not measured in oligodendrocytes; looking elsewhere.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for PACC1 in oligodendrocytes.

case closed: nothing better to follow up.

Receipts

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