Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | genetic association 0.05 (overall 0.03) | 0.05 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | compounds already reach it: daprodustat, roxadustat | 1.00 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | no papers tie it to Parkinson's yet | 1.00 |
| pathways Reactome | in no curated pathway | 0.00 |
No case: the score is under the bar. Receipt 6569
Sealed predictions
- P4HTM in dopamine neurons, braak+0.03 (p 0.946) → +0.06 (p 0.873)receipt 6575
Swarm cases
receipt 6575: P4HTM in dopamine neurons, braak
- power
- full sample -0.05 (p 0.854, n 18), 95% CI -0.50 to +0.43. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.05 (p 0.834, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.05 (p 0.847, n 18). could be the mix.
- skeptic
- leave-one-out range -0.14 to +0.06, sign flips 2; without severely affected donors -0.05 (p 0.854, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for P4HTM in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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