Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Gene record

OSCAR

osteoclast associated Ig-like receptor

translation score 0.57, read 2026-10-25; 2 sealed predictions, 0 held; 2 receipts.

Six readers

readerfoundscore
genetics
Open Targets		no genetic evidence; overall 0.01 from other evidence0.00
cell type
Human Protein Atlas		cell type enhanced in microglia (21 nCPM)1.00
chemistry
Open Targets		reachable by antibody0.45
trials
ClinicalTrials.gov		10 Parkinson's trials, 0 stopped1.00
literature
PubMed		6 Parkinson's papers of 1,2990.74
pathways
Reactome		2 pathways; mostly immune signalling0.90
proposal for OSCAR, translation score 0.57

Knock down and overexpress OSCAR in microglia; measure IL-1β and TNF release and surface HLA-DR and uptake and clearance of α-synuclein fibrils and NLRP3 inflammasome activation (IL-1β release).

Cell type
microglia
Direction
Both arms: public data does not say which way helps.
Molecular readout
IL-1β and TNF release and surface HLA-DR
Functional readout
uptake and clearance of α-synuclein fibrils and NLRP3 inflammasome activation (IL-1β release)
Rule-out
If neither arm moves IL-1β by 20% or more against non-targeting and empty-vector controls, across three independent differentiations, the hypothesis is wrong.
Lab request
CRISPRi knockdown and lentiviral overexpression of OSCAR in iPSC-derived microglia (iMGL); n = 3 differentiations; readouts: IL-1β and TNF release and surface HLA-DR; uptake and clearance of α-synuclein fibrils and NLRP3 inflammasome activation (IL-1β release). Controls: non-targeting guide, empty vector. About 8 to 10 weeks, most of it differentiation.

Sealed predictions

  1. OSCAR in microglia, braak+0.18 (p 0.635) → +0.37 (p 0.323)receipt 9281
  2. OSCAR in dopamine neurons, braak-0.25 (p 0.508) → -0.26 (p 0.493)receipt 9282

Swarm cases

receipt 9282: OSCAR in dopamine neurons, braak

power
full sample -0.34 (p 0.164, n 18), 95% CI -0.70 to +0.15. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: -0.37 (p 0.135, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.40 (p 0.097, n 18). could be the mix.
skeptic
leave-one-out range -0.47 to -0.25, sign flips 0; without severely affected donors -0.34 (p 0.164, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for OSCAR in dopamine neurons.

case closed: nothing better to follow up.

receipt 9281: OSCAR in microglia, braak

power
full sample +0.29 (p 0.246, n 18), 95% CI -0.21 to +0.67. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: +0.25 (p 0.310, n 18). does not hold up.
composition
microglia share of nuclei vs axis -0.11 (p 0.652); controlling for it: +0.28 (p 0.261, n 18). could be the mix.
skeptic
leave-one-out range +0.20 to +0.45, sign flips 0; without severely affected donors +0.29 (p 0.246, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for OSCAR in microglia.

case closed: nothing better to follow up.

Receipts

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