Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.04 from other evidence | 0.00 |
| cell type Human Protein Atlas | not detected in single-cell data | 0.00 |
| chemistry Open Targets | reachable by antibody | 0.36 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 1 Parkinson's papers of 4 | 0.91 |
| pathways Reactome | 1 pathway; mostly other | 0.30 |
No case: the score is under the bar. Receipt 6010
Sealed predictions
- OR10A4 in dopamine neurons, braak+0.55 (p 0.121) → +0.43 (p 0.251)receipt 6019
Swarm cases
receipt 6019: OR10A4 in dopamine neurons, braak
- power
- full sample +0.41 (p 0.091, n 18), 95% CI -0.07 to +0.74. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.43 (p 0.079, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.41 (p 0.091, n 18). could be the mix.
- skeptic
- leave-one-out range +0.33 to +0.49, sign flips 0; without severely affected donors +0.41 (p 0.091, n 18). robust.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for OR10A4 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
loading the receipts