Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Gene record

OBI1

ORC ubiquitin ligase 1

translation score 0.47, read 2026-10-18; 1 sealed predictions, 0 held; 2 receipts.

Six readers

readerfoundscore
genetics
Open Targets
genetic association 0.24 (overall 0.15)0.24
cell type
Human Protein Atlas
expressed broadly, no clear home in brain cells0.40
chemistry
Open Targets
hard to drug0.00
trials
ClinicalTrials.gov
no Parkinson's trials on record: an open field1.00
literature
PubMed
no papers tie it to Parkinson's yet1.00
pathways
Reactome
1 pathway; mostly other0.30

No case: the score is under the bar. Receipt 2187

Sealed predictions

  1. OBI1 in dopamine neurons, braakn/a → n/areceipt 2193

Swarm cases

receipt 2193: OBI1 in dopamine neurons, braak

cell type
OBI1 is not measured in dopamine neurons; looking elsewhere.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for OBI1 in dopamine neurons.

case closed: nothing better to follow up.

Receipts

loading the receipts