Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.05 from other evidence | 0.00 |
| cell type Human Protein Atlas | enriched in the midbrain (25 nTPM), where the nigral dopamine neurons sit | 0.90 |
| chemistry Open Targets | compounds already reach it: reminertant | 0.90 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 6 Parkinson's papers of 328 | 0.74 |
| pathways Reactome | 2 pathways; mostly other | 0.30 |
No case: the score is under the bar. Receipt 4818
Sealed predictions
- NTSR1 in dopamine neurons, braak-0.10 (p 0.805) → -0.42 (p 0.258)receipt 4856
Swarm cases
receipt 4856: NTSR1 in dopamine neurons, braak
- power
- full sample -0.30 (p 0.228, n 18), 95% CI -0.67 to +0.20. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.30 (p 0.228, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.36 (p 0.145, n 18). could be the mix.
- skeptic
- leave-one-out range -0.46 to -0.21, sign flips 0; without severely affected donors -0.30 (p 0.228, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for NTSR1 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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