parkinson, Parkinson's research notebook

Six readers

reader	found	score
genetics Open Targets	no genetic evidence; overall 0.11 from other evidence	0.00
cell type Human Protein Atlas	cell type enhanced, including oligodendrocyte progenitor cells; strongest in respiratory basal cells	0.75
chemistry Open Targets	a small-molecule pocket	0.60
trials ClinicalTrials.gov	no Parkinson's trials on record: an open field	1.00
literature PubMed	6 Parkinson's papers of 251	0.74
pathways Reactome	6 pathways; mostly other	0.30

No case: the score is under the bar. Receipt 2387

receipt 2395: NTN1 in dopamine neurons, braak

power: full sample -0.26 (p 0.289, n 18), 95% CI -0.65 to +0.23. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: -0.29 (p 0.243, n 18). does not hold up.
composition: dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.39 (p 0.114, n 18). could be the mix.
skeptic: leave-one-out range -0.42 to -0.17, sign flips 0; without severely affected donors -0.26 (p 0.289, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for NTN1 in dopamine neurons.

case closed: nothing better to follow up.

receipt 2394: NTN1 in oligodendrocytes, braak

power: full sample -0.10 (p 0.696, n 18), 95% CI -0.54 to +0.39. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: -0.09 (p 0.715, n 18). does not hold up.
composition: oligodendrocytes share of nuclei vs axis +0.03 (p 0.915); controlling for it: -0.28 (p 0.261, n 18). could be the mix.
skeptic: leave-one-out range -0.20 to +0.03, sign flips 3; without severely affected donors -0.10 (p 0.696, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for NTN1 in oligodendrocytes.

case closed: nothing better to follow up.

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