Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.00 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enhanced, including brain inhibitory neurons; strongest in thyrotrophs | 0.75 |
| chemistry Open Targets | reachable by antibody | 0.36 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | no papers tie it to Parkinson's yet | 1.00 |
| pathways Reactome | in no curated pathway | 0.00 |
No case: the score is under the bar. Receipt 15086
Sealed predictions
- NRSN1 in dopamine neurons, braak+0.17 (p 0.666) → +0.54 (p 0.130)receipt 15094
Swarm cases
receipt 15094: NRSN1 in dopamine neurons, braak
- power
- full sample +0.56 (p 0.016, n 18), 95% CI +0.12 to +0.81. the interval excludes zero: something may be there, smaller than a half can see.
- confounder
- adjusted for sex: +0.50 (p 0.034, n 18). holds up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.53 (p 0.025, n 18). not the mix.
- skeptic
- leave-one-out range +0.50 to +0.74, sign flips 0; without severely affected donors +0.56 (p 0.016, n 18). robust.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for NRSN1 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
loading the receipts