Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.00 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enhanced outside the brain (leydig cells) | 0.10 |
| chemistry Open Targets | hard to drug | 0.40 |
| trials ClinicalTrials.gov | 4 Parkinson's trials, 0 stopped | 1.00 |
| literature PubMed | 4 Parkinson's papers of 2,783 | 0.79 |
| pathways Reactome | in no curated pathway | 0.00 |
No case: the score is under the bar. Receipt 14373
Sealed predictions
- NRK in dopamine neurons, braak+0.05 (p 0.891) → +0.57 (p 0.108)receipt 14380
Swarm cases
receipt 14380: NRK in dopamine neurons, braak
- power
- full sample +0.31 (p 0.218, n 18), 95% CI -0.19 to +0.68. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.60 (p 0.0083, n 18). holds up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.63 (p 0.0053, n 18). not the mix.
- skeptic
- leave-one-out range +0.20 to +0.39, sign flips 0; without severely affected donors +0.31 (p 0.218, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for NRK in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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