Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.08 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enriched outside the brain (prostatic glandular cells) | 0.10 |
| chemistry Open Targets | reachable by antibody | 0.45 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 46 Parkinson's papers of 12,341 | 0.49 |
| pathways Reactome | 3 pathways; mostly iron and oxidative stress | 0.80 |
No case: the score is under the bar. Receipt 3325
Sealed predictions
- NPY in dopamine neurons, braak+0.19 (p 0.623) → -0.18 (p 0.646)receipt 3332
Swarm cases
receipt 3332: NPY in dopamine neurons, braak
- power
- full sample -0.02 (p 0.928, n 18), 95% CI -0.48 to +0.45. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.10 (p 0.696, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.05 (p 0.834, n 18). could be the mix.
- skeptic
- leave-one-out range -0.18 to +0.07, sign flips 8; without severely affected donors -0.02 (p 0.928, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for NPY in dopamine neurons.
case closed: nothing better to follow up.
Receipts
loading the receipts