Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.02 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enhanced, including brain inhibitory neurons; strongest in foveolar cells | 0.75 |
| chemistry Open Targets | a small-molecule pocket | 0.60 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 2 Parkinson's papers of 150 | 0.85 |
| pathways Reactome | 3 pathways; mostly other | 0.30 |
No case: the score is under the bar. Receipt 8502
Sealed predictions
- NPSR1 in dopamine neurons, braak+0.25 (p 0.520) → -0.46 (p 0.217)receipt 8510
Swarm cases
receipt 8510: NPSR1 in dopamine neurons, braak
- power
- full sample -0.11 (p 0.658, n 18), 95% CI -0.55 to +0.37. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.13 (p 0.615, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.24 (p 0.328, n 18). could be the mix.
- skeptic
- leave-one-out range -0.24 to +0.00, sign flips 2; without severely affected donors -0.11 (p 0.658, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for NPSR1 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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