Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.05 from other evidence | 0.00 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | compounds already reach it: crizotinib, ceritinib | 1.00 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 7 Parkinson's papers of 3,325 | 0.73 |
| pathways Reactome | 10 pathways; mostly protein handling | 0.90 |
No case: the score is under the bar. Receipt 5437
Sealed predictions
- NPM1 in dopamine neurons, braak-0.09 (p 0.820) → +0.40 (p 0.281)receipt 5445
Swarm cases
receipt 5445: NPM1 in dopamine neurons, braak
- power
- full sample +0.09 (p 0.735, n 18), 95% CI -0.40 to +0.53. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.05 (p 0.834, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.09 (p 0.715, n 18). could be the mix.
- skeptic
- leave-one-out range -0.02 to +0.22, sign flips 1; without severely affected donors +0.09 (p 0.735, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for NPM1 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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