Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.00 from other evidence | 0.00 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | a small-molecule pocket | 0.60 |
| trials ClinicalTrials.gov | 1214 Parkinson's trials, 9 stopped | 0.86 |
| literature PubMed | 8 Parkinson's papers of 1,465 | 0.71 |
| pathways Reactome | in no curated pathway | 0.00 |
No case: the score is under the bar. Receipt 16524
Sealed predictions
- NONO in dopamine neurons, braak+0.41 (p 0.273) → -0.40 (p 0.292)receipt 16532
Swarm cases
receipt 16532: NONO in dopamine neurons, braak
- power
- full sample +0.06 (p 0.800, n 18), 95% CI -0.42 to +0.52. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.19 (p 0.460, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.18 (p 0.471, n 18). could be the mix.
- skeptic
- leave-one-out range -0.03 to +0.23, sign flips 5; without severely affected donors +0.06 (p 0.800, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for NONO in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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