parkinson, Parkinson's research notebook

Six readers

reader	found	score
genetics Open Targets	no genetic evidence; overall 0.03 from other evidence	0.00
cell type Human Protein Atlas	cell type enhanced, including microglia; strongest in neutrophils	0.75
chemistry Open Targets	a small-molecule pocket	0.60
trials ClinicalTrials.gov	no Parkinson's trials on record: an open field	1.00
literature PubMed	14 Parkinson's papers of 1,069	0.64
pathways Reactome	1 pathway; mostly immune signalling	0.90

No case: the score is under the bar. Receipt 6376

receipt 6384: NLRP1 in dopamine neurons, braak

power: full sample -0.13 (p 0.621, n 18), 95% CI -0.56 to +0.36. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: -0.15 (p 0.549, n 18). does not hold up.
composition: dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.24 (p 0.346, n 18). could be the mix.
skeptic: leave-one-out range -0.24 to -0.01, sign flips 0; without severely affected donors -0.13 (p 0.621, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for NLRP1 in dopamine neurons.

case closed: nothing better to follow up.

receipt 6383: NLRP1 in microglia, braak

power: full sample +0.22 (p 0.384, n 18), 95% CI -0.28 to +0.62. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: +0.19 (p 0.455, n 18). does not hold up.
composition: microglia share of nuclei vs axis -0.11 (p 0.652); controlling for it: +0.19 (p 0.455, n 18). could be the mix.
skeptic: leave-one-out range +0.14 to +0.40, sign flips 0; without severely affected donors +0.22 (p 0.384, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for NLRP1 in microglia.

case closed: nothing better to follow up.

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