Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.08 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enhanced in other brain neurons (38 nCPM) | 1.00 |
| chemistry Open Targets | a small-molecule pocket | 0.60 |
| trials ClinicalTrials.gov | 10 Parkinson's trials, 2 stopped | 0.84 |
| literature PubMed | 10 Parkinson's papers of 692 | 0.69 |
| pathways Reactome | 1 pathway; mostly other | 0.30 |
No case: the score is under the bar. Receipt 3222
Sealed predictions
- NGB in dopamine neurons, braak+0.15 (p 0.699) → -0.72 (p 0.028)receipt 3230
Swarm cases
receipt 3230: NGB in dopamine neurons, braak
- power
- full sample -0.29 (p 0.243, n 18), 95% CI -0.67 to +0.20. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.26 (p 0.289, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.37 (p 0.127, n 18). could be the mix.
- skeptic
- leave-one-out range -0.46 to -0.20, sign flips 0; without severely affected donors -0.29 (p 0.243, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for NGB in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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