Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.02 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enhanced outside the brain (platelets) | 0.10 |
| chemistry Open Targets | hard to drug | 0.24 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 14 Parkinson's papers of 1,069 | 0.64 |
| pathways Reactome | 2 pathways; mostly other | 0.30 |
No case: the score is under the bar. Receipt 7594
Sealed predictions
- NFE2 in dopamine neurons, braak-0.42 (p 0.265) → +0.05 (p 0.907)receipt 7602
Swarm cases
receipt 7602: NFE2 in dopamine neurons, braak
- power
- full sample -0.16 (p 0.521, n 18), 95% CI -0.58 to +0.33. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.15 (p 0.549, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.26 (p 0.302, n 18). could be the mix.
- skeptic
- leave-one-out range -0.34 to -0.08, sign flips 0; without severely affected donors -0.16 (p 0.521, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for NFE2 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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