Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.06 from other evidence | 0.00 |
| cell type Human Protein Atlas | group enriched outside the brain (neuroendocrine cells) | 0.10 |
| chemistry Open Targets | hard to drug | 0.00 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 12 Parkinson's papers of 1,291 | 0.66 |
| pathways Reactome | 2 pathways; mostly other | 0.30 |
No case: the score is under the bar. Receipt 4738
Sealed predictions
- NEUROD1 in dopamine neurons, braak+0.02 (p 0.965) → -0.31 (p 0.414)receipt 4745
Swarm cases
receipt 4745: NEUROD1 in dopamine neurons, braak
- power
- full sample -0.12 (p 0.646, n 18), 95% CI -0.55 to +0.37. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.14 (p 0.573, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.21 (p 0.393, n 18). could be the mix.
- skeptic
- leave-one-out range -0.23 to -0.01, sign flips 0; without severely affected donors -0.12 (p 0.646, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for NEUROD1 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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