Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.17 from other evidence | 0.00 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | hard to drug | 0.00 |
| trials ClinicalTrials.gov | 2 Parkinson's trials, 1 stopped | 0.60 |
| literature PubMed | 7 Parkinson's papers of 190 | 0.73 |
| pathways Reactome | Reactome did not answer (Reactome: HTTP 521) | 0.00 |
No case: the score is under the bar. Receipt 2119
Sealed predictions
- NEFH in dopamine neurons, braak+0.27 (p 0.489) → +0.37 (p 0.334)receipt 2127
Swarm cases
receipt 2127: NEFH in dopamine neurons, braak
- power
- full sample +0.24 (p 0.337, n 18), 95% CI -0.26 to +0.64. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.25 (p 0.319, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.23 (p 0.365, n 18). could be the mix.
- skeptic
- leave-one-out range +0.16 to +0.44, sign flips 0; without severely affected donors +0.24 (p 0.337, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for NEFH in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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