Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.59 from other evidence | 0.00 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | compounds already reach it: metformin hydrochloride, me-344, metformin | 1.00 |
| trials ClinicalTrials.gov | 4 Parkinson's trials, 0 stopped | 1.00 |
| literature PubMed | 9 Parkinson's papers of 152 | 0.70 |
| pathways Reactome | 2 pathways; mostly mitochondrial quality control | 1.00 |
No case: the score is under the bar. Receipt 11456
Earlier readings: 2026-10-26 0.55; 2026-10-25 0.55; 2026-10-24 0.55; 2026-10-23 0.55.
Sealed predictions
- NDUFS2 in dopamine neurons, braak+0.10 (p 0.807) → -0.42 (p 0.262)receipt 0567
- NDUFS2 in dopamine neurons, resilience-0.08 (p 0.743) → -0.33 (p 0.358)receipt 0098
- NDUFS2 in dopamine neurons, braak-0.05 (p 0.768) → +0.01 (p 0.939)receipt 0097
Swarm cases
receipt 0567: NDUFS2 in dopamine neurons, braak
- power
- full sample -0.13 (p 0.615, n 18), 95% CI -0.56 to +0.36. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.14 (p 0.591, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.15 (p 0.544, n 18). could be the mix.
- skeptic
- leave-one-out range -0.28 to -0.01, sign flips 0; without severely affected donors -0.13 (p 0.615, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for NDUFS2 in dopamine neurons.
case closed: nothing better to follow up.
receipt 0098: NDUFS2 in dopamine neurons, resilience
- power
- full sample -0.14 (p 0.487, n 55), 95% CI -0.39 to +0.13. the interval is wide: not enough donors to tell.
- confounder
- adjusted for age, sex and PMI: -0.14 (p 0.474, n 55). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.12 (p 0.542); controlling for it: -0.13 (p 0.514, n 55). could be the mix.
- skeptic
- leave-one-out range -0.23 to -0.05, sign flips 0; without severely affected donors -0.15 (p 0.447, n 46). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "differs in resilient donors (Lewy pathology, no parkinsonism)" for NDUFS2 in dopamine neurons.
case closed: nothing better to follow up.
receipt 0097: NDUFS2 in dopamine neurons, braak
- power
- full sample -0.01 (p 0.934, n 84), 95% CI -0.22 to +0.21. the interval sits on zero: probably nothing there.
- confounder
- adjusted for age, sex and PMI: -0.03 (p 0.798, n 84). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis -0.72 (p 1.8e-14); controlling for it: -0.07 (p 0.533, n 84). could be the mix.
- skeptic
- leave-one-out range -0.04 to +0.03, sign flips 15; without severely affected donors -0.01 (p 0.901, n 75). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for NDUFS2 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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