Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.04 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enhanced, including brain excitatory neurons; strongest in smooth muscle cells | 0.75 |
| chemistry Open Targets | a small-molecule pocket | 0.60 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 11 Parkinson's papers of 361 | 0.67 |
| pathways Reactome | in no curated pathway | 0.00 |
No case: the score is under the bar. Receipt 5910
Sealed predictions
- NCS1 in dopamine neurons, braak-0.17 (p 0.656) → -0.80 (p 0.009)receipt 5918
Swarm cases
receipt 5918: NCS1 in dopamine neurons, braak
- power
- full sample -0.57 (p 0.014, n 18), 95% CI -0.82 to -0.14. the interval excludes zero: something may be there, smaller than a half can see.
- confounder
- adjusted for sex: -0.57 (p 0.014, n 18). holds up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.67 (p 0.0022, n 18). not the mix.
- skeptic
- leave-one-out range -0.66 to -0.52, sign flips 0; without severely affected donors -0.57 (p 0.014, n 18). robust.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for NCS1 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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